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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters namedA, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated duringembryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcriptionfactor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to theabdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and theNUP98 gene has been associated with myeloid leukemogenesis. (provided by RefSeq)
