HLA DRB5 Products

Antibodies
HLA DRB5 Antibody
HLA DRB5 Antibody
NBP2-14093
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
HLA DRB5 Antibody
HLA DRB5 Antibody
H00003127-D01P
Species: Hu
Applications: WB, ELISA
Host: Rabbit Polyclonal
Antibody Pairs
HLA DRB5 Antibody Pair
HLA DRB5 Antibody Pair
H00003127-PW1
Species: Hu
Applications: WB, IP
Lysates
HLA DRB5 Overexpression Lysat ...
HLA DRB5 Overexpression Lysate (De...
H00003127-T01
Species: Hu
Applications: WB
HLA DRB5 Overexpression Lysat ...
HLA DRB5 Overexpression Lysate (De...
H00003127-T03
Species: Hu
Applications: WB
Proteins
HLA DRB5 Recombinant Protein ...
HLA DRB5 Recombinant Protein Antigen
NBP2-14093PEP
Species: Hu
Applications: AC
RNAi
HLA DRB5 RNAi
HLA DRB5 RNAi
H00003127-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq]

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 3127
Alternate Names
  • HLA class II histocompatibility antigen, DR beta 5 chain
  • Dw2
  • dw2
  • MHC HLA-DR-beta chain
  • HLA-DRB
  • MHC HLA-DR-beta cell surface glycoprotein
  • FLJ76359
  • MHC class II HLA beta chain
  • DR9
  • MHC class II antigen DRB1*9
  • DR-9
  • leukocyte antigen class II
  • MHC class II antigen DRB5
  • human leucocyte antigen DRB5
  • DR beta-5
  • HLA class II histocompatibility antigen, DRB1-9 beta chain
  • DR2-beta-2
  • HLA class II histocompatibility antigen, DR-5 beta chain
  • major histocompatibility complex, class II, DR beta 5

Pathways for HLA DRB5

View related products by pathway and learn more about each of the pathways below.

Pathogenesis
Methylation
Translation
Aging
Dna Methylation
Oncogenesis

Research Areas for HLA DRB5

Find related products by research area and learn more about each of the different research areas below.

Asthma
Diabetes Research
Immunology

PTMs for HLA DRB5

Learn more about PTMs related to HLA DRB5.

Methylation

Bioinformatics Tool for HLA DRB5

Discover related pathways, diseases and genes to HLA DRB5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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