HLA DRB3 Products

Antibodies
Lysates
HLA DRB3 293T Cell Transient ...
HLA DRB3 293T Cell Transient Overe...
H00003125-T03
Species: Hu
Applications: WB
Proteins
Recombinant Human HLA DRB3 GS ...
Recombinant Human HLA DRB3 GST (N-...
H00003125-P01
Species: Hu
Applications: WB, ELISA, PA, AP

Description

HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq]

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 3125
Alternate Names
  • DR7
  • HLA class II histocompatibility antigen, DR beta 3 chain
  • HLA class II histocompatibility antigen, DRB1-7 beta chain
  • HLA-DR3B
  • HLA-DR52
  • HLA-DRB1
  • human leucocyte antigen DRB3
  • major histocompatibility complex, class II, DR beta 3
  • MGC117330
  • MHC class II antigen DR beta 3 chain
  • MHC class II antigen DRB3
  • MHC class II HLA-DR beta 3 chain

Research Areas for HLA DRB3

Find related products by research area and learn more about each of the different research areas below.

Asthma
Immunology

Bioinformatics Tool for HLA DRB3

Discover related pathways, diseases and genes to HLA DRB3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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