HLA DRB3 Products

Antibodies
HLA DRB3 Antibody
HLA DRB3 Antibody
H00003125-B02P
Species: Hu
Applications: WB, ELISA, Flow
Host: Mouse Polyclonal
HLA DRB3 Antibody
HLA DRB3 Antibody
NBP1-33666
Species: Hu
Applications: ICC/IF
Host: Rabbit Polyclonal
HLA DRB3 Antibody
HLA DRB3 Antibody
H00003125-D01P
Species: Hu
Applications: WB, ELISA
Host: Rabbit Polyclonal
Lysates
HLA DRB3 Overexpression Lysat ...
HLA DRB3 Overexpression Lysate (De...
H00003125-T01
Species: Hu
Applications: WB
HLA DRB3 Overexpression Lysat ...
HLA DRB3 Overexpression Lysate (De...
H00003125-T03
Species: Hu
Applications: WB
Proteins
HLA DRB3 Recombinant Protein
HLA DRB3 Recombinant Protein
H00003125-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
HLA DRB3 RNAi
HLA DRB3 RNAi
H00003125-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq]

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 3125
Alternate Names
  • HLA-DR52
  • MGC117330
  • MHC class II HLA-DR beta 3 chain
  • HLA-DRB1
  • MHC class II antigen DR beta 3 chain
  • HLA-DR3B
  • human leucocyte antigen DRB3
  • DR7
  • HLA class II histocompatibility antigen, DRB1-7 beta chain
  • MHC class II antigen DRB3
  • HLA class II histocompatibility antigen, DR beta 3 chain
  • major histocompatibility complex, class II, DR beta 3

Research Areas for HLA DRB3

Find related products by research area and learn more about each of the different research areas below.

Asthma
Immunology

Bioinformatics Tool for HLA DRB3

Discover related pathways, diseases and genes to HLA DRB3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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