Species: Hu, Mu
Applications: WB, ELISA
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Host: Rabbit Monoclonal
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP
Species: Hu
Applications: AC
Description
HIRA encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq]
Bioinformatics
| Product By Gene ID |
7290 |
| Alternate Names |
- DGCR1DiGeorge critical region gene 1
- HIR (histone cell cycle regulation defective) homolog A (S. cerevisiae)
- HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
- HIR
- TUP1
- TUP1-like enhancer of split protein 1
- TUPLE1protein HIRA
|
Research Areas for HIRA
Find related products by research area and learn more about each of the different research areas below.
Cell BiologyChromatin Modifiers
