HIRA Products

Description

HIRA encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq]

Bioinformatics

Entrez	7290 Human
Uniprot	NP_003316 Human NP_003316.3 Human P54198 (human) Human P54198 Human
Product By Gene ID	7290
Alternate Names	DGCR1DiGeorge critical region gene 1 HIR (histone cell cycle regulation defective) homolog A (S. cerevisiae) HIR histone cell cycle regulation defective homolog A (S. cerevisiae) HIR TUP1 TUP1-like enhancer of split protein 1 TUPLE1protein HIRA