Description
Under normoxic conditions, the alpha subunits of the transcriptional complex HIF are degraded by proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The HIF Prolyl Hydroxylases (HPHs) are four enzymes that are involved in this degradation pathway. They catalyze the hydroxylation of HIF-1 alpha and target it for degradation. Under hypoxic conditions, HIF Prolyl Hydroxylase is inhibited, allowing the HIF complex to form and signal Hypoxia Response Elements. HPHs are sometimes referred to as PHDs.
Bioinformatics
| Product By Gene ID |
54583 |
| Alternate Names |
- C1orf12HPH2
- EC 1.14.11
- EC 1.14.11.-
- ECYT3
- egl nine homolog 1 (C. elegans)
- egl nine homolog 1
- egl nine-like protein 1
- HIF prolyl hydroxylase 2
- HIF-PH2
- HIFPH2EGL nine (C.elegans) homolog 1
- HIF-prolyl hydroxylase 2
- HPH-2
- Hypoxia-inducible factor prolyl hydroxylase 2
- PHD2SM20
- Prolyl hydroxylase domain-containing protein 2
- SM-20
- zinc finger MYND domain-containing protein 6
- ZMYND6DKFZp761F179
|
Research Areas for HIF Prolyl Hydroxylases
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CancerHypoxia
