HIF Prolyl Hydroxylases Products

Antibody Packs
HIF Prolyl Hydroxylases Antib ...
HIF Prolyl Hydroxylases Antibody Pack
Species: Hu, Mu, Rt
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-P, ICC/IF, KD
Host: Rabbit


Under normoxic conditions, the alpha subunits of the transcriptional complex HIF are degraded by proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The HIF Prolyl Hydroxylases (HPHs) are four enzymes that are involved in this degradation pathway. They catalyze the hydroxylation of HIF-1 alpha and target it for degradation. Under hypoxic conditions, HIF Prolyl Hydroxylase is inhibited, allowing the HIF complex to form and signal Hypoxia Response Elements. HPHs are sometimes referred to as PHDs.


Product By Gene ID 54583
Alternate Names
  • EC 1.14.11
  • HIF-prolyl hydroxylase 2
  • EC 1.14.11.-
  • HPH-2
  • zinc finger MYND domain-containing protein 6
  • HIF-PH2
  • HIF prolyl hydroxylase 2
  • Prolyl hydroxylase domain-containing protein 2
  • egl nine-like protein 1
  • Hypoxia-inducible factor prolyl hydroxylase 2
  • egl nine homolog 1
  • SM-20
  • C1orf12HPH2
  • ZMYND6DKFZp761F179
  • HIFPH2EGL nine (C.elegans) homolog 1
  • PHD2SM20
  • ECYT3
  • egl nine homolog 1 (C. elegans)

Research Areas for HIF Prolyl Hydroxylases

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PTMs for HIF Prolyl Hydroxylases

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Bioinformatics Tool for HIF Prolyl Hydroxylases

Discover related pathways, diseases and genes to HIF Prolyl Hydroxylases. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Related HIF Prolyl Hydroxylases Blog Posts

Check out the latest blog posts on HIF Prolyl Hydroxylases.
HIF Prolyl Hydroxylase 1: A Key Regulator of HIF1A Levels
Hypoxia inducible factors (HIFs) are transcription factors that regulate the cellular response to decreases in oxygen levels. Under conditions of hypoxia HIFs activate the transcription of a diverse range of genes, resulting in increased oxygen delive...    Read more.
Read more HIF Prolyl Hydroxylases related blogs.