hcp-3 Products

Description

Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Not required for chromosome segregation during meiosis. Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, hcp-3 and H4 assembled in one hcp-3-H4 heterotetramer and two H2A-H2B heterodimers. The hcp-3-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers.

Bioinformatics

Entrez	176359 C. elegans
Uniprot	P34470 C. elegans
Alternate Names	hcp3

Research Areas for hcp-3

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modENCODE Antibodies