Description
H4/B, also known as histone cluster 4, H4, is 103 amino acids long, 11 kDA that is critical in the nucleosome by functioning in transcription regulation, DNA replication and repair, as well as chromosomal stability. H4/B participates in telomere maintenance, type II interferon signaling, signal transduction Activin A signaling regulation, and development of NOTCH1-mediated pathway for NF-KB activity modulation. It interacts with other genes such as HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, and HIST1H3E. It has been researched regarding its role in various diseases such as ovarian cancer, colon cancer, ceroid lipofuscinosis, fragile x syndrome, DNA topoisomerase II, lupus, carcinoma, hepatitis C, skin cancer, and hodgkin's lymphoma.
Bioinformatics
| Entrez |
Human
|
| Product By Gene ID |
8360 |
| Alternate Names |
- histone H4
- dJ221C16.9
- H4/b
- H4FB
- histone cluster 1, H4d
|
