GRK6 Products

Description

Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second messenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1; two forms of beta-adrenergic receptor kinase, GRK 2 (betaARK, betaARK1) and GRK 3 (betaARK2); IT-11 (GRK 4); GRK 5, GRK6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.

Bioinformatics

Entrez	2870 Human 26385 Mouse 59076 Rat
Uniprot	P43250 Human
Product By Gene ID	2870
Alternate Names	EC 2.7.11 EC 2.7.11.16 FLJ32135 G protein-coupled receptor kinase 6 GPRK6G protein-coupled receptor kinase GRK6

Research Areas for GRK6

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Protein Kinase