GPVI Products

Antibodies
GPVI Antibody
GPVI Antibody
NBP1-76941
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
GPVI Antibody (784808)
GPVI Antibody (784808)
MAB6758
Species: Mu
Applications: Flow, CyTOF-ready, ICC
Host: Rat Monoclonal
GPVI Antibody
GPVI Antibody
AF6758
Species: Mu
Applications: WB
Host: Sheep Polyclonal
Lysates
GPVI Overexpression Lysate (N ...
GPVI Overexpression Lysate (Native)
NBL1-11211
Applications: WB
Proteins
GPVI Recombinant Protein Anti ...
GPVI Recombinant Protein Antigen
NBP2-39074PEP
Species: Hu
Applications: AC
GPVI Blocking Peptide
GPVI Blocking Peptide
NBP1-76941PEP
Species: Hu
Applications: AC
GPVI Blocking Peptide
GPVI Blocking Peptide
NBP1-76359PEP
Species: Hu
Applications: AC
RNAi
GPVI RNAi
GPVI RNAi
H00051206-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 (PubMed 10961879)).(supplied by OMIM)

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 51206
Alternate Names
  • GPIV
  • platelet glycoprotein VI
  • Glycoprotein 6
  • GPVIplatelet collagen receptor
  • MGC138168
  • glycoprotein VI (platelet)

PTMs for GPVI

Learn more about PTMs related to GPVI.

Demethylation
Phosphorylation
Biotinylation
Glycosylation
Methylation

Bioinformatics Tool for GPVI

Discover related pathways, diseases and genes to GPVI. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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