GP1BB Products

GP1BB Antibody
GP1BB Antibody
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
GP1BB Antibody
GP1BB Antibody
Species: Hu, Mu
Applications: WB
Host: Rabbit Polyclonal
GP1BB Antibody
GP1BB Antibody
Species: Hu
Applications: WB
Host: Rabbit Polyclonal


Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alphachain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor(VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, andGPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling throughphosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated withBernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIbbeta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arisingfrom a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this producthas been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissuessuch as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signalwithin a separate gene (septin 5) located upstream of this gene. In the absence of polyadenylation from its ownimperfect site, the septin 5 gene uses the consensus polyA signal of this gene. (provided by RefSeq)


Entrez Human
Product By Gene ID 2812
Alternate Names
  • GPIbbeta
  • glycoprotein Ib platelet beta subunit
  • platelet membrane glycoprotein Ib beta
  • truncated platelet membrane glycoprotein Ib beta
  • GPIb-beta
  • platelet glycoprotein Ib beta chain
  • BS
  • BDPLT1
  • nuclear localization signal deleted in velocardiofacial syndrome
  • antigen CD42b-beta
  • glycoprotein Ib (platelet), beta polypeptide

Pathways for GP1BB

View related products by pathway and learn more about each of the pathways below.

Platelet Aggregation

Bioinformatics Tool for GP1BB

Discover related pathways, diseases and genes to GP1BB. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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