Glucocorticoid Receptor beta Products

ELISA Kits
Rat Glucocorticoid Receptor b ...
Rat Glucocorticoid Receptor beta E...
NBP2-82208
Species: Rt
Applications: ELISA
Mouse Glucocorticoid Receptor ...
Mouse Glucocorticoid Receptor beta...
NBP2-82207
Species: Mu
Applications: ELISA
Human Glucocorticoid Receptor ...
Human Glucocorticoid Receptor beta...
NBP2-82206
Species: Hu
Applications: ELISA

Description

Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism, and the immune and inflammatory responses. These compounds exert their effect through their interaction with the glucocorticoid receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain GR. The human GR exists in two forms, alpha and beta, which are thought to be the result of alternative splicing of a single gene. Sequence analysis indicates that the alpha and beta forms of human GR are 777 and 742 amino acids long, respectively. They are identical up to residue 727, after which they diverge. After ligand binding, the 94 kDa GR alpha isoform has been observed to translocate from the cytoplasm to the nucleus where it regulates gene expression. In contrast, the 90 kDa GR beta isoform does not appear to bind either glucocorticoid agonists or antagonists, and has been localized predominantly in the nucleus independent of hormone treatment in some human cell lines. Studies suggest that human GR beta might function as a dominant negative inhibitor of GR alpha activity.

Bioinformatics

Entrez Human
Uniprot Human
Product By Gene ID 2908
Alternate Names
  • glucocorticoid receptor
  • GCR
  • GRLNuclear receptor subfamily 3 group C member 1
  • GRGCCR
  • nuclear receptor subfamily 3, group C, member 1
  • nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Research Areas for Glucocorticoid Receptor beta

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction

PTMs for Glucocorticoid Receptor beta

Learn more about PTMs related to Glucocorticoid Receptor beta.

Methylation
Phosphorylation
Acetylation
Cleavage

Bioinformatics Tool for Glucocorticoid Receptor beta

Discover related pathways, diseases and genes to Glucocorticoid Receptor beta. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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