Description
Protein folding is monitored by multiple, sometimes overlapping, surveillance mechanisms within the ER. When erroneous protein folding is detected, the proteins are recycled through the ER associated degradation pathway. OS9 and HRD1 coordinate to induce protein degradation in this pathway; whereas, through an independent mechanism Derlin1 also affects ER associated degradation. Analysis of these proteins can assist in identifying the point of dysfunction when ER associated degradation is ineffective.
Research Areas for ER associated Degradation
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Unfolded Protein Response
