DUSP9 Products

Description

Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. The members of the dual-specificity phosphatase protein family include MKP-1/CL100 (3CH134), VHR, PAC1, MKP-2, hVH-3 (B23), hVH-5, MKP-3, MKP-X and MKP-4. Human MKP-1 maps to chromosome 5q34 and encodes a 367 amino acid, 39 kDa protein that dephosphorylates MAP kinase ERK2 on both Thr-183 and Tyr-185.

Bioinformatics

Entrez	1852 Human 293847 Rat 75590 Mouse
Uniprot	AAH60837.1 Human NM_001395 Human NP_001386 Human Q99956 Human
Product By Gene ID	1852
Alternate Names	dual specificity phosphatase 9 EC 3.1.3.16 EC 3.1.3.48 MAP kinase phosphatase 4 Mitogen-activated protein kinase phosphatase 4 MKP-4dual specificity protein phosphatase 9 MKP4serine/threonine specific protein phosphatase

Research Areas for DUSP9

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Signal Transduction