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DDX3Y, also known as ATP-dependent RNA helicase DDX3Y, is a 73.1 kDa 660 amino acid protein and is involved in altering and unwinding the secondary structure of RNA as a member of the DEAD box protein family. Current research is being conducted for diseases and disorders such as malaria, infertility, azoospermia, prostatitis, and spermatogenic failure. The protein interacts in the RIG-I-like receptor signaling pathway with RPAP1, UBC, POT1, ESR1, and SHBG.