CYP2A13 Products

Description

The immunosuppressant cyclosporin A (CsA) forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity. Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of the CsA and is encoded by a single unique gene conserved from yeast to humans. CyPA is involved in T cell differentiation and proliferation and is highly expressed in brain. CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication.

Bioinformatics

Entrez	1553 Human
Uniprot	AAI53001.1 Human NP_000757.2 Human Q16696 Human
Product By Gene ID	1553
Alternate Names	CPAD CYP2A CYPIIA13 cytochrome P450 2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 13 EC 1.14.14.1