Species: Hu
Applications: Bioactivity
Description
Cullin-4A (CUL4A) is a core component of multiple cullin-RING type E3
Ubiquitin ligase complexes that mediate the ubiquitination of proteins
involved in cell cycle progression, DNA repair and other processes. In the DCX complex (DDB1-CUL4-X-box) CUL4A serves as a scaffold that
organizes the DDB1-X-box recognition subunits with the RBX1 subunit and
contributes to catalysis through positioning of the substrate and an E2
ubiquitin-conjugating enzyme.
In vivo, the E3 ubiquitin ligase activity
of the DCX complex is dependent on neddylation of the cullin subunit,
though neddylation may be dispensable for some in vitro reactions.
Bioinformatics
