CPSF4 Products

Antibodies
CPSF4 Antibody
CPSF4 Antibody
NBP2-13868
Species: Hu, Mouse, Rat
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
CPSF4 Antibody
CPSF4 Antibody
NB100-79826
Species: Hu, Mu
Applications: WB, IP
Host: Rabbit Polyclonal
CPSF4 Antibody
CPSF4 Antibody
NB100-79827
Species: Hu, Mu
Applications: WB, IP
Host: Rabbit Polyclonal
Lysates
CPSF4 Overexpression Lysate ( ...
CPSF4 Overexpression Lysate (Denat...
H00010898-T01
Species: Hu
Applications: WB
CPSF4 Overexpression Lysate ( ...
CPSF4 Overexpression Lysate (Native)
NBL1-09448
Applications: WB
Proteins
CPSF4 Recombinant Protein Ant ...
CPSF4 Recombinant Protein Antigen
NBP2-13868PEP
Species: Hu
Applications: AC
CPSF4 Recombinant Protein
CPSF4 Recombinant Protein
NBP2-22783
Species: Hu
Applications: PAGE
RNAi
CPSF4 RNAi
CPSF4 RNAi
H00010898-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 10898
Alternate Names
  • cleavage and polyadenylation specific factor 4, 30kD subunit
  • Neb-1
  • NS1 effector domain-binding protein 1
  • no arches-like zinc finger protein
  • CPSF 30 kDa subunit
  • neb-1
  • No arches homolog
  • 30kD
  • cleavage and polyadenylation specific factor 4, 30kDa

Bioinformatics Tool for CPSF4

Discover related pathways, diseases and genes to CPSF4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.