Complement C8A/B/G Products

Antibodies
Complement C8A/B/G Antibody ( ...
Complement C8A/B/G Antibody (056B-...
NB100-64340
Species: Hu
Applications: WB, ELISA, Flow, IHC, IHC-Fr
Host: Mouse Monoclonal

Description

C8 is synthesised in the liver, monocytes and fibroblasts and is a plasma protein consisting of three non identical polypeptide chains. The alpha-chain (64kDa) and gamma chain (22kDa) are disulphide linked, these associate non-covalently with the beta-chain (64kDa), to form the native C8 molecule with a molecular weight of 151kDa. Normal plasma concentration is 80mg/L.C8 is one of the terminal proteins of the complement pathways. C8 binds to the membrane bound C5b-7, C5b-8 combines with C9 to form the membrane attack complex (MAC). The MAC forms a hydrophilic, protein walled, transmembrane channel, formation of which leads to cell lysis and destruction.

Bioinformatics

Entrez Human
Uniprot Human
Product By Gene ID 731
Alternate Names
  • complement component C8 alpha chain
  • complement component 8, alpha polypeptide

Pathways for Complement C8A/B/G

View related products by pathway and learn more about each of the pathways below.

Complement Activation
Disease Resistance
Neuroprotection
Dna Replication
Acute-phase Response
Immune Response
Pathogenesis
Viral Replication
Localization

PTMs for Complement C8A/B/G

Learn more about PTMs related to Complement C8A/B/G.

Phosphorylation
Glycosylation
Acetylation
Oxidation
Methylation
Deamidation

Bioinformatics Tool for Complement C8A/B/G

Discover related pathways, diseases and genes to Complement C8A/B/G. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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