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Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many Gprotein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase Cactivity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesisof phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-Ifamily, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgiapparatus. (provided by RefSeq)
