Cav1.2 Products

Description

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins.

Bioinformatics

Entrez	775 Human
Uniprot	NP_000710.5 Human
Product By Gene ID	775
Alternate Names	alpha-1 subunit CACH2 CACN2 CACNA1C CACNL1A1 calcium channel, voltage-dependent, L type, alpha 1C subunit cardic dihydropyridine-sensitive, alpha-1 subunit Cav1.2 CCHL1A1 L type, alpha 1 polypeptide, isoform 1, cardic muscle L type, alpha-1 polypeptide, isoform 1, cardiac muscle splice variant 10*

Research Areas for Cav1.2

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Cognition and Behavior
Phospho-Specific