CAB39 Products

Antibodies
CAB39 Antibody
CAB39 Antibody
NBP2-15658
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
CAB39 Antibody
CAB39 Antibody
H00051719-B01P
Species: Hu
Applications: WB, ELISA, PLA
Host: Mouse Polyclonal
CAB39 Antibody
CAB39 Antibody
NBP1-55393
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Lysates
CAB39 Overexpression Lysate ( ...
CAB39 Overexpression Lysate (Denat...
H00051719-T01
Species: Hu
Applications: WB
CAB39 Overexpression Lysate ( ...
CAB39 Overexpression Lysate (Native)
NBP2-09524
Applications: WB
CAB39 Overexpression Lysate ( ...
CAB39 Overexpression Lysate (Native)
NBP2-09523
Applications: WB
Proteins
Recombinant Human CAB39 Prote ...
Recombinant Human CAB39 Protein
NBP1-50834
Species: Hu
Applications: PAGE

Description

Mouse protein 25 alpha (MO25 alpha) is a 40-kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). MO25 alpha binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity (1). Skeletal muscle contraction results in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase (AMPKK). The LKB1-STE-related adaptor (STRAD)-mouse protein 25 (MO25) complex is the major AMPKK in skeletal muscle; however, LKB1-STRAD-MO25 activity is not increased by muscle contraction. This relationship suggests that phosphorylation of AMPK by LKB1-STRAD-MO25 during skeletal muscle contraction may be regulated by allosteric mechanisms (2).

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 51719
Alternate Names
  • Protein Mo25
  • calcium-binding protein 39
  • FLJ22682
  • MO25CGI-66
  • calcium binding protein 39

Pathways for CAB39

View related products by pathway and learn more about each of the pathways below.

Transport
Cell Growth
Cell Proliferation
Cell Migration
Ion Homeostasis

Research Areas for CAB39

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Signal Transduction

PTMs for CAB39

Learn more about PTMs related to CAB39.

Phosphorylation

Bioinformatics Tool for CAB39

Discover related pathways, diseases and genes to CAB39. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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