BFAR Products

Antibodies
BFAR Antibody
BFAR Antibody
NB100-56094
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
BFAR Antibody
BFAR Antibody
NB100-56093
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
BFAR Antibody
BFAR Antibody
NBP1-77111
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IF
Host: Rabbit Polyclonal
Lysates
BFAR Overexpression Lysate (N ...
BFAR Overexpression Lysate (Native)
NBP2-04359
Applications: WB
Proteins
BFAR Recombinant Protein
BFAR Recombinant Protein
H00051283-P01
Species: Hu
Applications: WB, ELISA, PA
BFAR Partial Recombinant Prot ...
BFAR Partial Recombinant Protein
H00051283-Q01
Species: Hu
Applications: WB, ELISA, PA
BFAR Peptide
BFAR Peptide
NBP1-77111PEP
Species: Hu
Applications: AC
RNAi
BFAR RNAi
BFAR RNAi
H00051283-R01V
Species: Hu
Applications: WB, RNAi SP
BFAR RNAi
BFAR RNAi
H00051283-R01
Species: Hu

Description

BAR (bifunctional apoptosis regulator) is a multidomain protein that was originally identified as an inhibitor of Bax-induced apoptosis (Zhang et al, 2000). Apoptosis induction can be divided up into two major pathways, extrinsic and intrinsic. The extrinsic pathway is represented by death receptor signaling and the intrinsic pathway depends on mitochondrial events. BAR is in anchored in intracellular membranes and is thought to be a scaffold protein that may bridge components of both extrinsic and intrinsic apoptosis pathways through its antiapoptotic domains: 1. BAR contains a DED (death effector domain)-like protein interaction domain that suppresses death receptor apoptosis signaling pathways. Death receptors such as the TNF (tumor necrosis factor)-family contain protein interaction domains called DD (death domains) in their cytosolic regions. DD-containing TNF receptor family members such as Fas aggregate upon binding ligand and bind to an adaptor protein FADD which contains both DD and DED domains. The Fas/FADD complexes bind to the caspase family members such as 8 and 10 which contain DEDs in their N-terminal prodomain. This is followed by proteolytic processing and caspase activation, thereby initiating a signal transduction cascade leading to activation of downstream effector caspases, substrate cleavage, and ultimate cell death. DED-containing antiapoptotic proteins like BAR function as transdominant apoptosis inhibitors by competing for binding to the DED domains of proapoptotic proteins like Fadd, caspase-8 and caspase-10, thereby preventing assembly of functional death-inducing complexes and hence activation of downstream apoptosis signaling cascades. 2. BAR also contains a domain that mediates interactions with Bcl-2 family proteins and that is required for suppression of Bax-induced cell death in yeast and mammalian cells. Although the physiological functions of BAR remain to be elucidated. BAR is highly expressed in the brain and expression patterns as well as functional data with neuronal cell lines suggest that BAR is involved in regulating neuronal survival (Roth et al. 2003). Additionally, subcellular localization studies indicate that BAR predominantly localizes to the endoplasmic reticulum (ER), irrespective of cell type. Bcl-2 family proteins also localize to the ER. There is important crosstalk between the ER and mitochondria in the execution of cell death. It is thought that both BAR and Bcl-2 proteins play a role in regulating cell death/apoptosis induced by ER stress. Dysregulation of ER homeostasis and apoptosis is thought to be involved in the pathogenesis of some human neuronal diseases, including Alzheimer's, Parkinson's, polyglutamine diseases, nueronal storage diseases, prion dieases, as well as acute neurodegeration from brain trauma (reviewed in Lindholm et al, 2006). Since BAR is normally widely expressed in the brain, it may have a cytoprotective function in helping neurons to survive for the entire lifetime of the organism by playing a central role in inhibiting ER initiated apoptosis.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 51283
Alternate Names
  • bifunctional apoptosis inhibitor
  • BARRNF47RING finger protein 47
  • bifunctional apoptosis regulator

Pathways for BFAR

View related products by pathway and learn more about each of the pathways below.

Cell Death
Induction Of Apoptosis
Cell Proliferation
Lipid Homeostasis
Pathogenesis
Antennal Development
Localization
Oncogenesis
Autophagy

Research Areas for BFAR

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Zinc Finger

PTMs for BFAR

Learn more about PTMs related to BFAR.

Phosphorylation

Bioinformatics Tool for BFAR

Discover related pathways, diseases and genes to BFAR. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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