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BCR/ABL Products


Description

The BCR gene is involved in the 9:22 translocation that generates the Philadelphia chromosome both in chronic myeloid leukemia (CML) and in a proportion of cases of acute lymphocytic leukemia (ALL). A 5' bcr sequence becomes fused to an abl sequence (including tyrosine kinase domain sequences) from chromosome 9 and results in the production of a chimaeric BCR-ABL protein with enhanced kinase activity. These antibodies may be useful for studies of the oncogene and have potential diagnostic and prognostic applications.

Bioinformatics

Entrez
613
Human
Uniprot
P11274
Alternate Names
  • ABL
  • ALL
  • BCR ABL fusion protein
  • BCR/ABL fusion protein
  • bcr/abl
  • Bcr/c abl oncogene protein
  • BCR-ABL fusion protein
  • BCRe18/ABL1e3 fusion protein
  • breakpoint cluster region protein
  • c-ABL
  • CML
  • D22S662
  • JTK7
  • p150
  • PHL

Research Areas for BCR/ABL

Find related products by research area and learn more about each of the different research areas below.

Protein Kinase
Signal Transduction