BAG5 Products

Antibodies
BAG5 Antibody
BAG5 Antibody
NB100-56091
Species: Hu, Mu, Rt, Bv, Ca
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
BAG5 Antibody
BAG5 Antibody
NBP1-86065
Species: Hu, Mu, Rt, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
BAG5 Antibody
BAG5 Antibody
H00009529-B01P
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Polyclonal
Antibody Pairs
BAG5 Antibody Pair
BAG5 Antibody Pair
H00009529-PW1
Species: Hu
Applications: WB, IP
BAG5 Antibody Pair
BAG5 Antibody Pair
H00009529-AP11
Species: Hu
Applications: S-ELISA
Lysates
BAG5 Overexpression Lysate (D ...
BAG5 Overexpression Lysate (Denatu...
H00009529-T01
Species: Hu
Applications: WB
BAG5 Overexpression Lysate (N ...
BAG5 Overexpression Lysate (Native)
NBL1-07903
Applications: WB
BAG5 Overexpression Lysate (N ...
BAG5 Overexpression Lysate (Native)
NBP2-09157
Applications: WB
Proteins
BAG5 Recombinant Protein
BAG5 Recombinant Protein
H00009529-P01
Species: Hu
Applications: WB, ELISA, PA
BAG5 Recombinant Protein Anti ...
BAG5 Recombinant Protein Antigen
NBP1-86065PEP
Species: Hu
Applications: AC
RNAi
BAG5 RNAi
BAG5 RNAi
H00009529-R01
Species: Hu
BAG5 RNAi
BAG5 RNAi
H00009529-R03
Species: Hu
BAG5 RNAi
BAG5 RNAi
H00009529-R02
Species: Hu

Description

The BAG (Bcl-2-associated anthanogene) proteins are a family of chaperone regulators that modulate a number of diverse processes including proliferation, survival, stress responses, tumorigenesis, neuronal differentiation, growth arrest and apoptosis (reviewed Takayama and Reed, 2001; Doong et al, 2002, and Doukhanina et al. 2006). BAG proteins have been characterized as co-chaperones and interact with the chaperone heat shock proteins 70, both constitutive Hsc70 and inducible Hsp70. BAG proteins bind through their BAG domain to the ATPase domain of Hsc70/Hsp70, and can modulate either positively or negatively the functions of the Hsc70/Hsp70 chaperone proteins. The BAG domain has been shown to contribute to the anti-apoptotic activity of BAG-family proteins. The anti-apoptotic activities of BAG-family proteins may be dependent on their interactions with Hsc70/Asp70 and/or binding to Bcl-2. In addition to the conserved BAG domain, BAG-family proteins also contain additional domains which enable them to interact with specific target proteins or to target them to specific locations within cells. The BAG family contains at least six family members, including BAG-1 and its various isoforms [including BAG-1S, BAG-1M (RAP46/HAP46), and BAG-1L, BAG2, BAG3 (CAIR-1; Bis,), BAG4 (SODD), BAG5 and BAG6 (Scythe, BAT3). The following amino acids (aa) lengths and molecular weights (kDa) have been described for human BAG proteins (reviewed in Takayama et al, 2001 and Doong et al, 2002): BAG-1 (230 aa., 34 kDa), BAG-1S (219 aa, 29 kDa), BAG-1M (274 aa, 46 kDa), BAG-1L (345 aa, 52 kDa), BAG-2 [212 aa; 24 kDa (Arndt et al. 2005)], BAG-3 (575 aa, 74 kDa), BAG-4 (456 aa; 60 kDa), BAG-5 ([442 aa; 51 kDa (Kalia et al. 2004)], and BAG-6 (1129 aa; 150 kDa).

Bioinformatics

Entrez Human
Human
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 9529
Alternate Names
  • KIAA0873
  • BAG-family molecular chaperone regulator-5
  • BAG family molecular chaperone regulator 5
  • BAG-5
  • Bcl-2-associated athanogene 5
  • BCL2-associated athanogene 5

Pathways for BAG5

View related products by pathway and learn more about each of the pathways below.

Pathogenesis
Cell Death
Neuron Death
Regulation Of Cell Death
Translation
Induction Of Apoptosis
Protein Folding
Protein Refolding

Research Areas for BAG5

Find related products by research area and learn more about each of the different research areas below.

Apoptosis

PTMs for BAG5

Learn more about PTMs related to BAG5.

Phosphorylation
Ubiquitination
Ubiquitinylation

Bioinformatics Tool for BAG5

Discover related pathways, diseases and genes to BAG5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related BAG5 Blog Posts

Check out the latest blog posts on BAG5.
BAG3 - Hsp70 is my friend!
The BAG proteins are a large family of chaperone regulators governing a wide range of cell processes such as proliferation, survival, stress response, tumorigenesis, neuronal differentiation, growth arrest and apoptosis as reviewed in Takayama et al1....    Read more.
Read more BAG5 related blogs.