ATP6V0E1 Products

Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Bioinformatics

Product By Gene ID

8992

Alternate Names

ATP6HVma21 ATP6V0 ATP6V0EVma21p ATPase, H+ transporting, lysosomal (vacuolar proton pump) 9kD ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 H(+)-transporting two-sector ATPase, subunit H M9.2 vacuolar ATP synthase subunit H vacuolar proton pump H subunit Vacuolar proton pump subunit e 1 vacuolar proton-ATPase subunit M9.2 V-ATPase 9.2 kDa membrane accessory protein V-ATPase H subunit V-ATPase M9.2 subunit V-ATPase subunit e 1 V-type proton ATPase subunit e 1