ATP Citrate Lyase Products

Description

ATP citrate lyase (ACLY), also known as ATP citrate synthase, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer of four identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. One of these products, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. NDPK has been found to phosphorylate ACLY and insulin to increase phosphorylation of ACLY (2).

Bioinformatics

Product By Gene ID	47
Alternate Names	ACLEC 2.3.3.8 ACLY ATP Citrate Lyase ATP citrate synthase ATP-citrate (pro-S-)-lyase ATP-citrate synthase ATPCL Citrate cleavage enzyme CLATP EC 2.3.3.8