Tumor grade refers to a measure of how abnormal cells from your tumor appear under the microscope. This can refer to the appearance of the cells or to the percentage that appear to be dividing. The higher the grade, the more aggressive and fast growing the cancer. Tumors are typically classified from least to most aggressive as grade I through IV. p19ARF works as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals. Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors. This result indicates that p19ARF is an important tumor suppressor. Cathepsin E (CTSE) is an intracellular aspartic protease belonging to pepsin superfamily and is highly homologous to the analogous aspartic protease cathepsin D. Human and mice subjects with a shortage of CTSE are often prone to atopic dermatitis. Increased levels of CTSE are observed in proliferative diseases such as gastric carcinoma, cervical cancer, and has been considered a promising marker for pancreatic duct cancer.
Research Areas for Aggressive Tumor Markers
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