Adenylate Cyclase Products

Description

B. pertussis Adenylate Cyclase is an enzymatic toxin that converts ATP to 3’-5’cyclic AMP and plays a role in the pathogenesis of whooping cough (1). The K_m for ATP of the enzyme is 0.6 mM (2). The enzyme activity is calmodulin (CaM) dependent with a K_d for CaM of 0.2 nM. The protein is synthesized as a large bifunctional precursor of 1706 amino acid residues, endowed with Adenylate Cyclase and haemolytic activity (3). The enzyme corresponds to amino acid 1 to 399 and is released from the precursor as a 43 kD fragment. The N-terminal portion (residues 1-235/237) harbors the catalytic site, whereas the C-terminal portion (residues 235/237-399) corresponds to the main CaM-binding domain of the enzyme (4).

Bioinformatics

Uniprot	P15318
Product By Gene ID	107
Alternate Names	Adenylate Cyclase