Description
Caspase 3 (CASP3) is a member of the cysteine-aspartic acid protease (caspase) family that is involved in the execution-phase of cell apoptosis.
There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Caspase 3 is considered an effector, as it is activated in the apoptotic cell both by extrinsic (death ligand) and intrinsic (mitochondrial) pathways. Specifically, procaspase is activated when the procaspase is cleaved at a particular residue. Activated Caspase 3 then cleaves numerous substrates to effect the morphological changes associated with apoptosis.
Caspase 3 antibodies are important tools for apoptosis studies and research on the caspase family mediated apoptosis signaling pathway.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
836 |
| Alternate Names |
- Apopain
- apoptosis-related cysteine protease
- CASP-3
- caspase 3, apoptosis-related cysteine peptidase
- caspase-3
- CPP-32
- CPP32B
- CPP32SREBP cleavage activity 1
- Cysteine protease CPP32
- EC 3.4.22
- EC 3.4.22.56
- PARP cleavage protease
- procaspase3
- Protein Yama
- SCA-1
- Yama
|
Research Areas for active/cleaved Caspase-3
Find related products by research area and learn more about each of the different research areas below.
ApoptosisCancerCaspases
