alpha Adducin Products

Description

Adducin is a membrane skeletal protein that binds to actin filaments (F-actin) and promotes the association of spectrin with F-actin to form a spectrin-actin meshwork beneath plasma membranes (1-2). Adducin is a heterodimeric protein that consists of related subunits; alpha and beta, or alpha and gamma subunits (3). Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinase C (PKC), and protein kinase A (PKA) (4). PKA specifically phosphorylates Ser408, Ser436, and Ser481 located in the neck domain of alpha Adducin. Phosphorylation of Adducin alpha by Rho-kinase at Thr445 and Thr480 enhances the F-actin-binding activity of Adducin alpha (5).

Bioinformatics

Entrez	118 Human 24170 Rat
Product By Gene ID	118
Alternate Names	ADDA adducin 1 (alpha) alpha-adducin erythrocyte adducin alpha subunit Erythrocyte adducin subunit alpha MGC3339 MGC44427

Research Areas for alpha Adducin

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Phospho-Specific