p62/SQSTM1 Antibody (R-162-100)
p62/SQSTM1 Antibody
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anti-Ubiquitin-binding protein p62 antibody, biosensis, anti-Protein kinase C-zeta-interacting protein antibody, anti-PKC-zeta-interacting protein antibody, anti-phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa antibody, anti-p60 antibody, anti-EBIAP antibody, anti-EBI3-associated protein of 60 kDa antibody |
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p62/SQSTM1 Antibody Summary: | | Gene: | SQSTM1 |
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| Purity: | Whole antisera |
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| Host: | Rabbit |
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| | Specificity: | The specificity was confirmed by immunohistochemical analysis on paraffin embedded human brain. |
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| Publications: | Antibody has been mentioned in at least 10 Publications. |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional p62/SQSTM1 Products p62/SQSTM1 Antibody Details: | Immunogen: | A synthetic peptide (IGAALDTIQYSKH) corresponding to the C-terminal part of human Sequestosome 1 conjugated to the Blue Carrier Protein has been used as the immunogen. The peptide is homologous with the corresponding sequence derived from Sequestosome 1 protein in mouse, rat and bovine. |
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| Localization: | Accession Number: p60_HUMAN ; p60_MOUSE ; p60_RAT ; p60_BOVINE ; |
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This antibody is expected to recognise p60 in mouse, rat and bovine. See the immunogen field also. |
| Uses: | This antibody is useful for immunohistochemistry-P |
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| Dilutions: | Immunohistochemistry-Paraffin 1:500-1:5000 |
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| Unit Size: | 0.1 ml |
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| Concentration: | lyoph |
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Notes: Add diH20 for desired concentration. Packaging: | Storage: | Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles. |
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| Buffer: | lyophilized |
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| Preservative: | No Preservative |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: FUNCTION: Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. SUBUNIT: Homooligomer or heterooligomer; may form homotypic arrays. Interacts directly with PRKCI and PRKCZ (Probable). Forms ternary complexes with PRKCZ and KCNAB2 or PRKCZ and GABBR3. Also interacts with KCNAB1, GABRR1, GABRR2 and GABRR3. Forms an NGF-induced complex with IKBKB, PRKCI and TRAF6. Interacts with EBI3, LCK, RASA1, PRKCZ, PRKCI, NR2F2, NTRK1, NTRK2, NTRK3, NBR1, MAP2K5, TRIM55 and MAPKAPK5. Interacts with the proteasome subunits PSMD4 and PSMC2. Interacts with K63-polyubiquitinated MAPT/TAU. Interacts with IKBKB through PRKCZ and PRKCI. Interacts with NGFR through TRAF6 and bridges that complex to NTRK1. Forms a complex with MAP2K5 and PRKCZ or PRKCI. Component of a ternary complex with PAWR and PRKCZ. Upon TNF-alpha stimulation, interacts with RIPK1 problably bridging IKBKB to the TNF-R1 complex composed of TNF-R1/TNFRSF1A, TRADD and RIPK1. Forms a complex with JUB/Ajuba, PRKCZ and TRAF6. INTERACTION: P54725:RAD23A; NbExp=1; IntAct=EBI-307104, EBI-746453; SUBCELLULAR LOCATION: Cytoplasm. Sarcomere. Endosome; late endosome. Nucleus. In cardiac muscles localizes to the sarcomeric band. Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing.
This product is distributed on behalf of Biosensis Pty. Ltd. of Australia. | |  |
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Reviews (0) Related Products (40) Working with p62/SQSTM1
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Working with p62/SQSTM1
p62/SQSTM1 Antibody Images (0)
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Publications (10)p62/SQSTM1 Antibody Product Specific:- Ciani B, et al. J. Biol. Chem. 278:37409-37412(2003).
- ood D.A, et al. Bone 35:277-282(2004). ;
more... - ocking L.J, et al.J. Bone Miner. Res. 19:1013-1017(2004). ;
- Marcus S.L, et al. J. Biol. Chem. 271:27197-27200(1996). ;
- adlamudi R.K, et al. J. Biol. Chem. 271:20235-20237(1996). ;
- ark I, et al. Proc. Natl. Acad. Sci. U.S.A. 92:12338-12342(1995). ;
- Stumptner C, et al. Am. J. Pathol. 154:1701-1710(1999). ;
- Vadlamudi R.K., Shin J. FEBS Lett. 435:138-142(1998). ;
- Joung I, et al. Proc. Natl. Acad. Sci. U.S.A. 93:5991-5995(1996). ;
- Devergne O, et al. J. Virol. 70:1143-1153(1996). ;
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Related ProductsLysates (3)Peptides and ProteinsPrimary Antibodies (30)| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| p62/SQSTM1 Antibody | NBP1-48320 | Hu, Mu, Rt, Sh | ICC, IF, WB | (2) | (1) | | | | p62/SQSTM1 Antibody | NBP1-42822 | Hu, Mu, Rt | ICC, IF, WB | (2) | (1) | | | | p62/SQSTM1 Antibody | NBP1-42821 | Hu, Mu, Rt | ICC, IF, WB | (2) | (1) | | | | p62/SQSTM1 Antibody (2C11) | H00008878-M01 | Hu, Mu | ELISA, IF, WB | (3) | (8) | | | | p62/SQSTM1 Antibody | NBP1-49956 | Hu, Mu | IP, WB | (1) | | | | | ... and 25 more. See All » |
RNAi (1)Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Rabbit IgG Antibody [HRP] | NB730-H | Rb | ELISA, ICC, IHC-P, WB | | (5) | | | | Rabbit IgG Antibody [FITC] | NB730-F | Rb | ICC, IHC-P | | (1) | | | | Rabbit IgG Antibody [Biotin] | NB730-B | Rb | ELISA, ICC, IHC-P, WB | | | | | | Rabbit IgG, H/L Chains Antibody [DyLight 488] | NBP1-72944 | Rb | FLISA, IF, WB | (3) | | | | | Rabbit IgG Antibody [Alkaline Phosphatase] | NB730-AP | Rb | ELISA, ICC, IHC-P, WB | | (1) | | | | See All » |
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