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Mitogen Activated Protein Kinase (MAPK) signaling pathways are responsible for regulating a variety of cellular activities, including proliferation, differentiation and apoptosis, in response to certain environmental stimuli. Three major MAPK pathways have been identified in mammals: MAPK/ERK, SAPK/JNK and p38 MAPK. The four p38 MAPK family members (p38, MAPK11, SAPK3 & SAPK4) are activated by external stress, inflammatory cytokines or UV radiation. Once activated, this pathway initiates production of the pro-apoptotic transcription factors PAX6, ELK1, CHOP, MEF2, ATF2, ETS1, MAX, p53, CREB, NFkB p65, ATF1 and ER81. |
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Explore Your Pathways With Novus Explorer! This free bioinformatics tool is designed to facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Novus is proud to offer top quality research reagents for nearly every p38 MAPK related protein, with some of our most popular included in the table below. Please feel follow the protein name links for additional products for each protein, or the catalog number links for more detail on the individual antibodies. |
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p38 MAPK Signaling Pathway Antibodies for Human Samples
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IHC analysis of cPLA2
in human colon carcinoma using NB100-92066. |








