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The extracellular matrix (ECM) is the external framework found between individual cells that comprise higher order structures like tissues and organs. The ECM composition of vertebrates is dominated by a class of molecules known as collagens - each with unique features suited for a particular function and location. Collagen proteins are made up of three subunit polypeptides that vary in length...

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B7H4 is a co-stimulatory protein though to function as a negative regulator of T-cell mediated immunity by blocking proliferation, cell cycle progression and interleukin-2 (IL-2) production. Because B7H4-deficient mice are only minimally affected, it appears that B7H4 is involved in fine tuning of the T-cell mediated immune response. B7H4 is expressed on activated T-...

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