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FOXO1 belongs to the very large Forkhead family of transcription factors which contain a conserved distinct DNA-binding domain known as the Forkhead Box, or FOX. The Forkhead domain is a 100 amino acid long motif capable of binding and bending DNA, and is also known as a “winged helix”. Forkhead family members are involved in a very diverse and wide range of physiological...

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Hemostasis, or blood clotting, follows tissue injury and involves the deployment of essential plasma procoagulants (such as prothrombin, and Factors X, IX, V, and VIII) that trigger the blood coagulation cascade. This cascade leads to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Defects in Factor VIII and the coagulation cascade result in hemophilia A...

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