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TLR2 is a member of the broad family of Toll-like receptors (TLR) that play an important role in pathogen recognition and innate immunity. TLRs, like other pattern recognition receptors (PRRs), recognize endogenous ligands released during cell or tissue damage (DAMPs) as well as exogenous, pathogen associated ligands from bacteria or viruses (PAMPs).  Upon recognition of a specific ligand,...

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Beta-catenin is a cytosolic, 88 kDa intracellular protein associated with cell surface cadherin glycoproteins. It is a member of the larger calcium-dependent catenin family that includes alpha-catenin, beta-catenin, and gamma-catenin (also known as plakoglobin). Beta-catenin enters the nucleus to interact with TCF/LEF (Lymphoid enhancer factor-1) transcription factor family. It is normally...

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