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PCSK9: To neuron or not to neuron

PCSK9 (Proprotein convertase subtilisin/kexin type 9) is a member of the proteinase K subfamily of the secretory subtilase family. It is first produced as a soluble zymogen that then undergoes an autocatalytic processing within the endoplasmic reticulum (ER). PCSK9 functions in cholesterol homeostas ...

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PINK1 and its role in Parkinson's disease

PINK1 (PTEN induced putative kinase 1) is a mitochondrial serine/threonine kinase which maintains mitochondrial function/integrity, provides protection against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins, and is involved in the clearance of ...

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