Researchers have long wondered how developing tissues and organs are signaled to stop growing upon reaching maturity. The Hippo (or SWH) signaling pathway has been shown to be responsible for controlling organ growth and size by limiting cell proliferation and promoting apoptosis. At low cell densities, the co-activators YAP/TAZ induce the expression of transcription factors that lead the pathway toward cell proliferation. However at higher cell densities, membrane-bound regulators trigger YAP/TAZ phosphorylation, thereby preventing them from entering the nucleus to induce the pro-growth transcription factors. Mutations of the Hippo protein lead to overgrowth that is similar to the unchecked cell proliferation found in tumors.
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Novus Biologicals offers a number of top quality antibodies for the HIPPO signaling pathway proteins, with some of our most popular included in the table below. Please feel follow the protein name links for additional products for each protein, or the catalog number links for more detail on the individual antibodies.
HIPPO Signaling Pathway Antibodies for Human Samples
HIPPO Signaling Pathway References
- Buttitta LA, Edgar BA. How size is controlled: from Hippos to Yorkies. Nat Cell Biol. 2007 Nov;9(11):1225-7. [PMID: 17975546]
- Zeng Q, Hong W. The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals. Cancer Cell. 2008 Mar;13(3):188-92. [PMID: 18328423]
- Badouel C, Garg A, McNeill H. Herding Hippos: regulating growth in flies and man. Curr Opin Cell Biol. 2009 Dec;21(6):837-43. [PMID: 19846288]
- Varelas X, Miller BW, Sopko R, et al. The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell. 2010 Apr 20;18(4):579-91. [PMID: 20412773]
- Bao Y, Hata Y, Ikeda M, Withanage K. Mammalian Hippo pathway: from development to cancer and beyond. J Biochem. 2011 Apr;149(4):361-79. [PMID: 21324984]
- Zhao B, Tumaneng K, Guan KL. The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol. 2011 Aug 1;13(8):877-83. [PMID: 21808241]
- Liu W, Wu J, Xiao L, et al. Regulation of Neuronal Cell Death by c-Abl-Hippo/MST2 Signaling Pathway. PLoS One. 2012;7(5):e36562. [PMID: 22590567]