Support: 1-888-506-6887
Worldwide flag      (Choose your country)  
Home ยป HIPPO Signaling Pathway
HIPPO Signaling Pathway

Researchers have long wondered how developing tissues and organs are signaled to stop growing upon reaching maturity. The Hippo (or SWH) signaling pathway has been shown to be responsible for controlling organ growth and size by limiting cell proliferation and promoting apoptosis. At low cell densities, the co-activators YAP/TAZ induce the expression of transcription factors that lead the pathway toward cell proliferation.  However at higher cell densities, membrane-bound regulators trigger YAP/TAZ phosphorylation, thereby preventing them from entering the nucleus to induce the pro-growth transcription factors. Mutations of the Hippo protein lead to overgrowth that is similar to the unchecked cell proliferation found in tumors.

 

Hippo Pathway

Explore Your Pathways With Novus Explorer! This free bioinformatics tool is designed to facilitate scientific exploration of related genes, diseases and pathways based on co-citations.

Novus Biologicals offers a number of top quality antibodies for the HIPPO signaling pathway proteins, with some of our most popular included in the table below. Please feel follow the protein name links for additional products for each protein, or the catalog number links for more detail on the individual antibodies.

 

HIPPO Signaling Pathway Antibodies for Human Samples

Name Catalog# Species Applications
FAT1 NBP1-84565 Hu IHC-P, IHC
FAT4 NBP1-78381 Hu, Mu ICC/IF, IHC-P, IHC
DACH1 NBP1-85320 Hu ICC/IF, IHC, IHC-P
DACH2 NBP1-89476 Hu ICC/IF, IHC, IHC-P
KIBRA NBP1-92052 Hu WB, ICC/IF, IHC, IHC-P
KIBRA NBP1-92053 IHC, IHC-P IHC, IHC-P
Merlin NBP1-87757 Hu WB, ICC/IF, IHC, IHC-P
Merlin NBP1-33531 Hu, Mu, Rt WB, IHC, IHC-P
MST1 24480002 Hu WB, ELISA, IHC, IHC-P, IP
MST1 NBP1-85330 Hu WB, IHC, IHC-P
MST2 NBP1-48017 Hu, Ca, Mk WB, IHC, IHC-P
SAV1 H00060485-M02 Hu WB, ELISA, ICC/IF, IP, S-ELISA
LATS1 NBP1-62088 Hu, Mu ELISA, IHC, IHC-P
LATS2 NB200-199 Hu, Mu WB, IP, PLA
YAP1 NB110-58358 Hu, Mu WB, ICC/IF, IHC, IHC-P, IP
SAV1 NBP2-13282 Hu WB, IHC, IHC-P
TAZ NB110-58359 Hu, Mu, Rt WB, ICC/IF, IP
TAZ NBP1-85067 Hu, Mu WB, ICC/IF, IHC, IHC-P
TAZ NBP2-01114 Hu WB, FLOW, ICC/IF
TAZ NBP1-88511 Hu WB, ICC/IF, IHC, IHC-P
14-3-3 gamma NB100-407 Hu, Mu, Rt, Bv, Ch, Ze WB, ICC/IF
RUNX2 NBP1-77461 Hu, Mu ICC/IF, IHC, IHC-P
TEAD3 NBP1-83949 Hu ICC/IF, IHC, IHC-P
DACH1 NBP1-00136 Hu WB, PEP-ELISA
DACH2 NBP1-80001 Hu, Mu, Ca, Ch, Xp, Ze WB
DCHS1 NBP2-13901 Hu IHC, IHC-P
FAT1 NB100-2693 Dr WB, ELISA, ICC/IF
FAT3 NBP1-90642 Hu IHC, IHC-P
FRMD6 NBP1-90725 Hu, Mu WB, ICC/IF, IHC, IHC-P
LATS1 NBP1-58271 Hu, Mu, Rt WB

HIPPO Signaling Pathway References

  1. Buttitta LA, Edgar BA. How size is controlled: from Hippos to Yorkies. Nat Cell Biol. 2007 Nov;9(11):1225-7. [PMID:  17975546]
  2. Zeng Q, Hong W. The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals. Cancer Cell. 2008 Mar;13(3):188-92. [PMID: 18328423]
  3. Badouel C, Garg A, McNeill H. Herding Hippos: regulating growth in flies and man. Curr Opin Cell Biol. 2009 Dec;21(6):837-43. [PMID: 19846288]
  4. Varelas X, Miller BW, Sopko R, et al. The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell. 2010 Apr 20;18(4):579-91. [PMID: 20412773]
  5. Bao Y, Hata Y, Ikeda M, Withanage K. Mammalian Hippo pathway: from development to cancer and beyond. J Biochem. 2011 Apr;149(4):361-79. [PMID: 21324984]
  6. Zhao B, Tumaneng K, Guan KL. The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol. 2011 Aug 1;13(8):877-83. [PMID: 21808241]
  7. Liu W, Wu J, Xiao L, et al. Regulation of Neuronal Cell Death by c-Abl-Hippo/MST2 Signaling Pathway. PLoS One. 2012;7(5):e36562. [PMID: 22590567]