p62/SQSTM1 Antibody (NB110-74805)
p62/SQSTM1 Antibody
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anti-Sequestosome 1 antibody, anti-ZIP3 antibody, anti-ubiquitin-binding protein p62 antibody, anti-SQSTM1 antibody, anti-phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa antibody, anti-PDB3 antibody, anti-p62B antibody, anti-p60 antibody, Anti-OSIL antibody, anti-EBIAP antibody, anti-EBI3-associated protein of 60 kDa antibody, anti-A170 antibody |
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p62/SQSTM1 Antibody Summary: | | Gene: | SQSTM1 |
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| Purity: | Whole antisera |
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| Host: | Rabbit |
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| | | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional p62/SQSTM1 Products p62/SQSTM1 Antibody Details: | Immunogen: | A synthetic peptide as a part of sequestosome-1 (ubiquitin-binding protein p62, p60, EBIAP) conjugated to immunogenic carrier protein has been used as the immunogen. |
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| Uses: | Western Blot, Immunohistochemistry Paraffin and Frozen |
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| Dilutions: | Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot 1:200 to 1:5000 |
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| Unit Size: | 0.15 ml |
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| Concentration: | lyoph |
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| Positive Controls: | 1 Positive Controls |
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Notes: Reconstitute in 0.15 ml of sterile water. Centrifuge to remove any insoluble material. When reconstituting, glycerol (1:1) may be added for an additional stability. Packaging: | Storage: | Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles. |
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| Buffer: | Lyophilized |
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| Preservative: | No Preservative |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: FUNCTION: Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. SUBCELLULAR LOCATION: Cytoplasm. Late endosome. Nucleus. Note=Sarcomere. In cardiac muscles localizes to the sarcomeric band. Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma. TISSUE SPECIFICITY: Ubiquitously expressed.
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Reviews (0) Related Products (40) Exploring p62/SQSTM1 Working with p62/SQSTM1
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p62/SQSTM1 Antibody Images (0)
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Publications (10)p62/SQSTM1 Antibody Background References:- Olsen J.V, et al. Cell 127:635-648(2006).
- Nousiainen M, et al. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
more... - Ciani B, et al. J. Biol. Chem. 278:37409-37412(2003).
- Hocking L.J, et al. Hum. Mol. Genet. 11:2735-2739(2002).
- Good D.A, et al. Bone 35:277-282(2004).
- Hocking L.J, et al. J. Bone Miner. Res. 19:1122-1127(2004).
- Vadlamudi R.K, et al. J. Biol. Chem. 271:20235-20237(1996).
- Stumptner C, et al. Am. J. Pathol. 154:1701-1710(1999).
- Joung I, et al. Proc. Natl. Acad. Sci. U.S.A. 93:5991-5995(1996).
- Devergne O, et al. J. Virol. 70:1143-1153(1996).
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Jump to: Positive Controls, Lysates, Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies
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Related ProductsPositive ControlsLysates (3)Peptides and ProteinsPrimary Antibodies (30)| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| p62/SQSTM1 Antibody | NBP1-48320 | Hu, Mu, Rt, Sh | ICC, IF, WB | (2) | (1) | | | | p62/SQSTM1 Antibody | NBP1-42822 | Hu, Mu, Rt | ICC, IF, WB | (2) | (1) | | | | p62/SQSTM1 Antibody | NBP1-42821 | Hu, Mu, Rt | ICC, IF, WB | (2) | (1) | | | | p62/SQSTM1 Antibody (2C11) | H00008878-M01 | Hu, Mu | ELISA, IF, WB | (3) | (8) | | | | p62/SQSTM1 Antibody | NBP1-49956 | Hu, Mu | IP, WB | (1) | | | | | ... and 25 more. See All » |
RNAi (1)Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Rabbit IgG Antibody [HRP] | NB730-H | Rb | ELISA, ICC, IHC-P, WB | | (5) | | | | Rabbit IgG Antibody [FITC] | NB730-F | Rb | ICC, IHC-P | | (1) | | | | Rabbit IgG Antibody [Biotin] | NB730-B | Rb | ELISA, ICC, IHC-P, WB | | | | | | Rabbit IgG, H/L Chains Antibody [DyLight 488] | NBP1-72944 | Rb | FLISA, IF, WB | (3) | | | | | Rabbit IgG Antibody [Alkaline Phosphatase] | NB730-AP | Rb | ELISA, ICC, IHC-P, WB | | (1) | | | | See All » |
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