p62/SQSTM1 Antibody (NB110-61677)
p62/SQSTM1 Antibody
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Anti-A170 antibody, anti-ZIP3 antibody, Anti-ZIP 3 antibody, anti-ubiquitin-binding protein p62 antibody, anti-SQSTM 1 antibody, Anti-Sequestosome-1 antibody, anti-phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa antibody, anti-Phosphotyrosine independent ligand for the Lck SH2 domain p62 antibody, anti-PDB3 antibody, anti-PDB 3 antibody, Anti-Paget disease of bone 3 antibody, anti-p62B antibody, anti-p60 antibody, Anti-Oxidative stress induced like antibody, Anti-OSIL antibody, anti-ORCA antibody, anti-EBIAP antibody, anti-EBI3-associated protein of 60 kDa antibody, anti-EBI 3 associated protein of 60 kDa antibody |
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p62/SQSTM1 Antibody Summary: | | Gene: | SQSTM1 |
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| Purity: | Affinity purified |
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| Host: | Rabbit |
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| | Specificity: | Confirmed by immunohistochemical/ western blot analysis of normal and diseased human brain.
In western blot the antibody recognizes 4 major bands of 130, 62, 45 and 22 kDa in human brain homogenate. The antibody may also recognize some proteins containing SQSTM1 domains from other species as 80, 62 and 47 kDa proteins are identified in rat sympathetic ganglia. Preincubation of the antibody with the immunizing peptide abolishes all reactivity in both human brain homogenate and rat sympathitic ganglia. |
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| Publications: | Antibody has at least 1 Background Reference. |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional p62/SQSTM1 Products p62/SQSTM1 Antibody Details: | Immunogen: | Synthetic peptide as part of human Ubiquitin Interactive Motif (UIM)derived from p62 protein, also known as SQSTM1. (accession: AAH01874) |
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| Localization: | Lyophilized. Reconstitute with 0.02 ml sterile water. |
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This antibody is reactive against human. Not yet tested in other species. |
| Uses: | Western Blot and Immunohistochemistry-Paraffin/Frozen |
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| Dilutions: | Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin 1-4 ug/ml, Western Blot |
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| Unit Size: | 0.02 mg |
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| Concentration: | Please see the vial label for concentration. |
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Packaging: | Storage: | Store at 4 °C short term. Aliquot and store at -80 °C long term. Avoid freeze-thaw cycles. |
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| Preservative: | No Preservative |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: SQSTM1/p62 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. More recently, a role for SQSTM1/p62 in macroautophagic removal of intracellular protein aggregates has also been proposed. Studies involving the cellular depletion of SQSTM1/p62 have indicated a need for its association with LC3 and the aggregate proteins in order to facilitate correct formation of the autophagosome.
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Working with p62/SQSTM1
p62/SQSTM1 Antibody Images (0)
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Publications (1)p62/SQSTM1 Antibody Background References:- Strausberg, R.L et al. Proc. Natl. Acad. Sci. U.S.S. 99 (26) 16899-16903 (2002)
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Related ProductsLysates (3)Peptides and ProteinsPrimary Antibodies (30)| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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