PSGL-1/CD162 Antibody (HECA-452) [FITC]

Cutaneous Lymphocyte-assiciated Antigen (CD162 ) is a 140 kD homodimer protein recognized by a unique mAb HECA-452. It is expressed on T lymphocytes in skin, subsets of peripheral blood memory T cells, NK cells, memory B cells and dendritic cells, as well as on monocytes, granulocytes and activated endothelial cells. CD162 is a carbohydrate epitope of sialic acid- and fucose-modified P-selectin glycoprotein ligand-1 (PSGL-1), a surface glycoprotein expressed on majority of peripheral blood leukocytes. CLA is a subset ligand for E-selectin, P-selectin, and L-selectin. It plays a role in memory lymphocyte homing, tethering and rolling. Treatment of activated HUVEC cells with HECA-452 antibody inhibits lymphocyte adhesion. The HECA-452 antibody is cross-reactive with mouse CLA, and is suitable for staining formalin-fixed paraffin embedded tissue sections.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 applications: B/N, IF/IHC.

Showing Publications 1 - 3 of 3.

Publications using NB100-78041	Applications	Species
Duijvestijn AM, Horst E, Pals ST et al. High endothelial differentiation in human lymphoid and inflammatory tissues defined by monoclonal antibody HECA-452. Am J Pathol. 1988-01-01 [PMID: 3276207] (IF/IHC)	IF/IHC
Berg EL, Yoshino T, Rott LS et al. The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1. J Exp Med. 1991-12-01 [PMID: 1720810] (B/N)	B/N
Picker LJ, Kishimoto TK, Smith CW et al. ELAM-1 is an adhesion molecule for skin-homing T cells. Nature. 1991-02-01 [PMID: 1705666] (IF/IHC)	IF/IHC

Array NB100-78041

• PSGL-1/CD162 Antibodies
• PSGL-1/CD162 Lysate
• PSGL-1/CD162 Protein
• PSGL-1/CD162 Proteins and Enzymes
• PSGL-1/CD162 ELISA