ITGB1BP2 is a muscle-specific protein cloned by a rat created by Branccio’s group in Italy that was found to interact with the cytoplasmic domain of integrin beta 11. It is expressed only in heart and skeletal muscle but is not essential for normal development and differentiation of these tissues. Branccio’s group published a follow-up study in Nature Medicine using an ITGB1BP2 antibody that the protein plays a critical role in sensing mechanical stress due to pressure overloading2. This response protects against subsequent compensatory dilated cardiomyopathy and contractile dysfunction. Further work from this group confirmed that ITGB1BP2 nucleotide variations are found in families of patients with hypertension and/or primary dilated or hypertrophic cardiomyopathy3.
Gu et al believe that altered ITGB1BP2 expression and signaling parallels the recovery of cardiac function (or lack of it) after myocardial infarctions (MI) and can be measured as one component in a profile panel of remodeling markers4. A recently submitted grant5 suggests that used a monoclonal ITGB1BP2 antibody for western blot to show test the functional activity of recombinant melusin. IGB1BP2 activates the downstream AKT and ERK signaling pathways by acting as a chaperone and binding to the Hsp90 machinery.
Novus Biologicals offers ITGB1BP2 reagents for your research needs including:
- US8658598 B2