LCAT Antibody (NB110-57158)
LCAT Antibody (EPR1384Y)
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anti-Lecithin cholesterol acyltransferase antibody, anti-Phospholipid cholesterol acyltransferase antibody, anti-Phosphatidylcholine sterol acyltransferase antibody, |
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LCAT Antibody (EPR1384Y) Summary: | | Gene: | LCAT |
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| Purity: | Tissue culture supernatant |
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| Host: | Rabbit |
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| | Specificity: | A synthetic peptide corresponding to residues on the C-terminus of human LCAT was used as an immunogen. |
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| Publications: | Antibody has at least 3 Background References. |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional LCAT Products LCAT Antibody (EPR1384Y) Details: | Clone: | EPR1384Y |
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| Isotype: | IgG |
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| Immunogen: | Synthetic peptide corresponding to residues on the C terminus of human LCAT. |
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Reacts in human. Does not react in mouse or rat. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis, Immunocytochemistry, Immunohistochemistry-Paraffin, immunoprecipitation and Western Blot |
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| Dilutions: | Flow Cytometry 1:10, Immunocytochemistry 1:100 - 250, Immunohistochemistry-Paraffin 1:100 - 250, immunoprecipitation 1:100, Western Blot 1:10000 |
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| Unit Size: | 0.1 ml |
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| Concentration: | This product is unpurified. Concentration is not relevant. |
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Packaging: | Storage: | Aliquot and store at -20 °C or -80 °C. Avoid freeze-thaw cycles. |
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| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
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| Preservative: | 0.01% Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: The enzyme, lecithin cholesterol acyltransferase (LCAT), is responsible for the esterification of plasma cholesterol mediating the transfer of an acyl group from lecithin to the 3-hydroxy group of cholesterol (1). Esterification of cholesterol in plasma is mediated by LCAT. In patients with familial LCAT deficiency only trace amounts or no LCAT protein is found. Heterozygotes for this disorder have approximately half the normal amount of the enzyme. LCAT reactivity is essential for normal lipoprotein metabolism and for a proper equilibrium between tissue and plasma cholesterol (2). Cholesterol transport in circulation and its removal from tissues depends on the activity of lecithin cholesterol LCAT. LCAT is a soluble enzyme that converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lyso-phosphatidylcholines on the surface of high-density lipoproteins (3).
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Images (3) Reviews (0) Related Products (9) Exploring LCAT Working with LCAT
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Jump to: Publications, Images, Protocols/Procedures, Ask a Question
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Working with LCAT
LCAT Antibody (EPR1384Y) Images (3) Immunohistochemistry: LCAT Antibody (EPR1384Y) [NB110-57158] - Immunohistochemical staining of paraffin-embedded human brain using anti-LCAT (cat. #110-57158). |  Western Blot: LCAT Antibody (EPR1384Y) [NB110-57158] - Western blot analysis on human serum using anti-LCAT (cat. # 110-57158), dilution 1:10,000. |  Immunofluorescent: LCAT Antibody (EPR1384Y) [NB110-57158] - Immunofluorescent staining of HeLa cells using anti-LCAT (cat. #110-57158). |
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Publications (3)LCAT Antibody (EPR1384Y) Background References:- Jonas A, Biochem Biophys Acta 1529(1-3):245-56, 2000.
- Frohlich J, et al. Clin Biochem 15(6):269-78, 1982.
more... - Taramelli R, et al. Hum Genet 85(2):195-9, 1990.
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Jump to: Lysates, Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies
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