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Insulin R/CD220 [p Tyr1361] Antibody

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Product Details

Summary
Product Discontinued
View other related Insulin R/CD220 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-51404
    • Availability
      Product Discontinued

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Insulin R/CD220 [p Tyr1361] Antibody Summary

Immunogen
Synthetic phosphopeptide derived from human Insulin Receptor around the phosphorylation site of Tyrosine 1361.
Modification
p Tyr1361
Specificity
p-IR (Y1361) pAb detects endogenous levels of IR protein only when phosphorylated at Y136
Clonality
Polyclonal
Host
Rabbit
Gene
INSR
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000
Application Notes
Western blot (WB) analysis of p-IR (Y1361) pAb in extracts from THP1 cells.
Immunohistochemistry (IHC) analyzes of p-IR (Y1361) pAb in paraffin-embedded human breast carcinoma tissue.
Theoretical MW
95 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Insulin R/CD220 [p Tyr1361] Antibody

  • CD 220
  • CD220 antigen
  • CD220
  • EC 2.7.10
  • EC 2.7.10.1
  • HHF5
  • INSR
  • Insulin R
  • insulin receptor
  • InsulinR
  • IR

Background

Insulin receptor plays a major part in the regulation of glucose homeostasis, which when malfunctioning can result in diabetes and cancer. Encoded by the INSR gene, insulin receptor has two isoforms produced by alternative splicing, HIR-B and HIR-A.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Insulin R/CD220 [p
Tyr1361] Antibody
NBP1-51404
Insulin R/CD220 [p Tyr1361] Antibody
Species: Hu, Mu, Rt
Applications: WB, IHC

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Product General Protocols

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FAQs for Insulin R/CD220 Antibody (NBP1-51404). (Showing 1 - 1 of 1 FAQ).

  1. Has this antibody been tested for cross reactivity (on Western) with IGF-1R?
    • Insulin receptor and IGF-1R share just 57% similarity and the immunogen region shares less than 30% similarity, so this antibody should not cross-react.

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Bioinformatics

Gene Symbol INSR
Entrez
Uniprot