Apolipoprotein A-I/ApoA1 Antibody Summary
| Immunogen |
Purified human apolipoprotein A1 |
| Specificity |
This product reacts with human apolipoprotein A1 and does not react with other human plasma proteins. In ELISA the following reactivities are observed:
Human apolipoprotein A1 100%
Human apolipoprotein B <3%
Human albumin <1%
Apolipoprotein A1 is a single polypeptide with a molecular weight of 28 kDa. It is the major protein component of high density lipoprotein particles and functions in preventing the accumulation of cholesterol loaded macrophages which deposit on the arterial wall as foam cells. |
| Clonality |
Polyclonal |
| Host |
Sheep |
| Gene |
APOA1 |
| Purity |
Immunogen affinity purified |
| Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Reactivity Notes
Human. Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Buffer |
No buffer |
| Preservative |
Sodium Azide |
| Concentration |
LYOPH |
| Purity |
Immunogen affinity purified |
| Reconstitution Instructions |
Please contact technical support for detailed reconstituion instruction. |
Alternate Names for Apolipoprotein A-I/ApoA1 Antibody
Background
Apolipoprotein A I promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18 amino acid signal peptide is removed co-translationally and a 6 amino acid propeptide is cleaved post-translationally. Apolipoprotein A I is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease.
The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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FAQs for Apolipoprotein A-I/ApoA1 Antibody (NB100-62353) (0)
Control Lysate(s)
Secondary Antibodies
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Isotype Controls
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