ADAM 23 antibody

Chicken Polyclonal anti-ADAM 23

Catalog Number: NB100-75282	Price: $295.00

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Background:

ADAM23 is a non-catalytic metalloprotease-like protein. It is highly expressed in the brain, primarily in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole, and weakly expressed in the heart. 3 isoforms are produced by alternative splicing, alpha, beta and gamma. ADAM23 may play a role in cell-cell and cell-matrix interactions.

May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.

Alternate Names:

anti-A disintegrin and metalloproteinase domain 23 antibody, anti-MDC 3 antibody, anti-Metalloproteinase like disintegrin like and cysteine rich protein 3 antibody

Host:

Chicken

Immunogen:

The immunogen for this antibody was a sequence from 72a.a. to 144a.a. from ADAM 23(a 832a.a. long protein)

Isotype:

IgY

Reference Sequence:

O75077

Theoretical Molecular Weight:

91926 Da

Localization:

Nucleus.

Species Reactivity:

This antibody is reactive against Human.
Other species have not been tested.

Uses:

Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000. Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
Other applications have not been tested.

Dilutions:

Suggested working dilutions *
Western Blot
* Investigator should determine optimal working dilutions.

Packaging:

0.05 mg Immunogen affinity purified Chicken antisera

Buffer:

Phosphate-Buffered Saline.

Preservative:

No Preservative

Storage:

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Limitations:

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 6 months from date of receipt.

General References:

[1] Takada,H., Imoto,I., Tsuda,H., Nakanishi,Y., Ichikura,T., Mochizuki,H., Mitsufuji,S., Hosoda,F., Hirohashi,S., Ohki,M. and, et al. ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation
[2] Costa,F.F., Colin,C., Shinjo,S.M., Zanata,S.M., Marie,S.K., Sogayar,M.C. and Camargo,A.A. ADAM23 methylation and expression analysis in brain tumors
[3] Brandenberger,R., Wei,H., Zhang,S., Lei,S., Murage,J., Fisk,G.J., Li,Y., Xu,C., Fang,R., Guegler,K., Rao,M.S., Mandalam,R.,, et al. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation
[4] Cal,S., Freije,J.M., Lopez,J.M., Takada,Y. and Lopez-Otin,C., et al. ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism
[5] Roberts,C.M., Tani,P.H., Bridges,L.C., Laszik,Z. and Bowditch,R.D., et al. MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes
[6] , Sagane K., Ohya Y., Hasegawa Y., Tanaka I. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain.
[7] , Cal S., Freije J.M.P., Lopez J.M., Takada Y., Lopez-Otin C. ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alpha v beta 3 integrin through an RGD-independent mechanism.
[8] , Sun Y.P., Deng K.J., Wang F., Zhang J., Huang X., Qiao S., Zhao S. Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains.

Gene Id:

8745

Gene System:

ADAM23

Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. ( anti-ADAM23 )

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