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TRAF3IP2 Antibody

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Product Details

Summary
Product Discontinued
View other related TRAF3IP2 Primary Antibodies

Order Details


    • Catalog Number
      NB100-56317
    • Availability
      Product Discontinued

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TRAF3IP2 Antibody Summary

Immunogen
A mixture of synthetic peptides corresponding to amino acids 341-351 (CSFPGLPRHQDQPHHQ), 91-104 (CLRTQVLEDSEDSF) and 562-574 (PRGPLPTLQVVPLC) of human ACT1 was used as immunogen, GenBank no. gi|10242290|gb|AAG15367.1|AF274303_1.
Specificity
In MCF-7, an approx. 60 kDa band is observed.
Clonality
Polyclonal
Host
Rabbit
Gene
TRAF3IP2
Purity
Protein G purified
Innovator's Reward
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Applications/Dilutions

Reactivity Notes

Cross reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for TRAF3IP2 Antibody

  • ACT1DKFZP586G0522
  • adapter protein CIKS
  • C6orf2
  • C6orf4chromosome 6 open reading frame 5
  • C6orf5DKFZp586G0522
  • C6orf6MGC3581
  • CIKSchromosome 6 open reading frame 2
  • Connection to IKK and SAPK/JNK
  • NFkB-activating protein ACT1
  • Nuclear factor NF-kappa-B activator 1
  • TRAF3 interacting protein 2
  • TRAF3-interacting protein 2

Background

NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus (3). External stimuli such as tumor necrosis factor or other cytokines, such as IL-1 results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes (2). Recently, Li et al. (1) have isolated a cDNA coding for a protein named Act1 (NF- B activator 1). Act1 cDNA codes for a protein containing 574 aa with a predicated molecular mass of 60 kDa. Act1 protein contains a helix-loop-helix domain in its N-terminal portion and a coiled-coil structure at the C terminus. Act1 lacks any catalytic domain, however, it activates IKK through the helix-loop-helix domain. The activation of NF- B by Act1 appears to be through the NIK-IKK complex, because a NIK dominant-negative mutant protein inhibited Act1-induced NF- B activation. IL-1 responsive pathway is also necessary for Act1 function. Act1 mRNA is expressed in a variety of tissues, with high level in thymus, kidney and placenta; moderate level in heart, skeletal muscle, colon, liver, lung and small intestine; and at a very low level in brain, spleen, and peripheral blood leukocytes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol TRAF3IP2
Entrez