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The antibody is an agonistic antibody useful for detection of TNF-R II. It can be used for immunoassays, Western blotting, flow cytometry and immunoprecipitation. The reactivity of the antibody with cellbound or soluble TNF-Receptor is not inhibited by high concentrations of TNF-a. Minimal crossreactivity is present with human TNF-a.
Cross-reacts with Human. Not yet tested in other species.
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
0.1 mg/ml
Purity
IgG purified
Alternate Names for TNF RII/TNFRSF1B Antibody
CD120b antigen
CD120b
Etanercept
p75 TNF receptor
p75TBPII
p75TNFR
soluble TNFR1B variant 1
TNF RII
TNFBRp80 TNF-alpha receptor
TNF-R2
TNFR2TNFR1B
TNF-R75
TNFR80
TNFRII
TNF-RII
TNF-R-II
TNFR-II
TNFRSF1B
tumor necrosis factor beta receptor
tumor necrosis factor binding protein 2
Tumor necrosis factor receptor 2
tumor necrosis factor receptor superfamily member 1B
tumor necrosis factor receptor superfamily, member 1B
Tumor necrosis factor receptor type II
Background
Tumor Necrosis Factor (TNF) is a cytokine whose function is mediated through two distinct cell surface receptors (TNF Receptor I and TNF Receptor II) that are included in the TNF receptor superfamily along with FAS antigen and CD40. TNF receptors I and II are 55 and 75 kDa members, respectively, of a family of cell surface molecules including nerve growth factor receptor, Fas/Apo1, CD30, OX40, and 4-1BB, which are characterized by cysteine rich motifs in the extracellular domain.
TNF Receptor II (p75, CD120b) is present on most cell types (including monocytes, endothelial cells, Langerhans cells, and macrophages) and is considered to play a role in cell stimulation by TNF alpha. TNF Receptor II molecule is shown to be responsible for stimulation of activated T lymphocytes by TNF alpha.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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