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TNF RII/TNFRSF1B Antibody

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Product Details

Summary
Product Discontinued
View other related TNF RII/TNFRSF1B Primary Antibodies

Order Details


    • Catalog Number
      NB600-1106
    • Availability
      Product Discontinued

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TNF RII/TNFRSF1B Antibody Summary

Immunogen
extra-cellular part of the TNF-R II and with the soluble receptor.
Localization
Type II membrane protein
Specificity
The reacts with the extra-cellular part of the TNF-R II and with the soluble receptor.
Clonality
Polyclonal
Host
Rabbit
Gene
TNFRSF1B
Purity
IgG purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunoassay
  • Immunoprecipitation
  • Western Blot
Application Notes
The antibody is an agonistic antibody useful for detection of TNF-R II. It can be used for immunoassays, Western blotting, flow cytometry and immunoprecipitation. The reactivity of the antibody with cellbound or soluble TNF-Receptor is not inhibited by high concentrations of TNF-a. Minimal crossreactivity is present with human TNF-a.
Control
TRAF-2 Overexpression Lysate
Publications
Read Publication using NB600-1106.

Reactivity Notes

Cross-reacts with Human. Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
0.1 mg/ml
Purity
IgG purified

Alternate Names for TNF RII/TNFRSF1B Antibody

  • CD120b antigen
  • CD120b
  • Etanercept
  • p75 TNF receptor
  • p75TBPII
  • p75TNFR
  • soluble TNFR1B variant 1
  • TNF RII
  • TNFBRp80 TNF-alpha receptor
  • TNF-R2
  • TNFR2TNFR1B
  • TNF-R75
  • TNFR80
  • TNFRII
  • TNF-RII
  • TNF-R-II
  • TNFR-II
  • TNFRSF1B
  • tumor necrosis factor beta receptor
  • tumor necrosis factor binding protein 2
  • Tumor necrosis factor receptor 2
  • tumor necrosis factor receptor superfamily member 1B
  • tumor necrosis factor receptor superfamily, member 1B
  • Tumor necrosis factor receptor type II

Background

Tumor Necrosis Factor (TNF) is a cytokine whose function is mediated through two distinct cell surface receptors (TNF Receptor I and TNF Receptor II) that are included in the TNF receptor superfamily along with FAS antigen and CD40. TNF receptors I and II are 55 and 75 kDa members, respectively, of a family of cell surface molecules including nerve growth factor receptor, Fas/Apo1, CD30, OX40, and 4-1BB, which are characterized by cysteine rich motifs in the extracellular domain. TNF Receptor II (p75, CD120b) is present on most cell types (including monocytes, endothelial cells, Langerhans cells, and macrophages) and is considered to play a role in cell stimulation by TNF alpha. TNF Receptor II molecule is shown to be responsible for stimulation of activated T lymphocytes by TNF alpha.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TNF RII/TNFRSF1B Antibody (NB600-1106)(1)

We have publications tested in 1 confirmed species: Human.


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Bioinformatics

Gene Symbol TNFRSF1B
Entrez