TNF RII/TNFRSF1B Antibody Summary
| Immunogen |
Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Mouse) (C terminal). |
| Epitope |
Extra-cellular part of the receptor. |
| Localization |
Type II membrane protein |
| Specificity |
Mouse TNF-R II and the soluble receptor. Minimal crossreactivity is present with mouse TNF alpha. |
| Clonality |
Polyclonal |
| Host |
Rabbit |
| Gene |
TNFRSF1B |
| Purity |
IgG purified |
| Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
| Dilutions |
- Flow Cytometry
- Immunohistochemistry
- Immunoprecipitation
- Western Blot
|
| Application Notes |
The antibody can be used in immuno-assays, for Western blot, immunohistochemistyr, flow cytometry and immunoprecipitation. The reactivity of the antibodies with cell-bound or soluble TNF-Receptor is not inhibited by high concentrations of TNF-alpha. |
| Control |
|
Reactivity Notes
Cross-reacts with Mouse, Human and Rat. Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze. |
| Buffer |
PBS with 0.2% BSA |
| Preservative |
0.02% Sodium Azide |
| Concentration |
0.1 mg/ml |
| Purity |
IgG purified |
Alternate Names for TNF RII/TNFRSF1B Antibody
Background
Tumor Necrosis Factor (TNF) is a cytokine whose function is mediated through two distinct cell surface receptors (TNF Receptor I and TNF Receptor II) that are included in the TNF receptor superfamily along with FAS antigen and CD40. TNF receptors I and II are 55 and 75 kDa members, respectively, of a family of cell surface molecules including nerve growth factor receptor, Fas/Apo1, CD30, OX40, and 4-1BB, which are characterized by cysteine rich motifs in the extracellular domain.
TNF Receptor II (p75, CD120b) is present on most cell types (including monocytes, endothelial cells, Langerhans cells, and macrophages) and is considered to play a role in cell stimulation by TNF alpha. TNF Receptor II molecule is shown to be responsible for stimulation of activated T lymphocytes by TNF alpha.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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FAQs for TNF RII/TNFRSF1B Antibody (NB110-2054) (0)
Control Lysate(s)
Secondary Antibodies
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Isotype Controls
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