MDR1 Antibody Summary:

Species:	Hu
Applications:	WB
Clonality:	Polyclonal

Gene:	ABCB1
Purity:	Immunogen affinity purified
Host:	Rabbit

Specificity:	This product is specific for p170/MDR/ p-Glycoprotein

Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.

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MDR1 Antibody Details:

Isotype:	IgG
Immunogen:	Synthetic peptide corresponding to C-terminus of human p-glycoprotein.

Species Reactivity:

This product is specific for Human.

Applications:

Uses:	This product is useful for Western Blot.
Dilutions:	Western Blot
Unit Size:	0.1 ml
Concentration:	Please see the vial label for concentration.

Packaging:

Storage:	Store at 4 °C. Do not freeze.
Buffer:	10mM PBS/1% BSA buffer pH 7.4
Preservative:	0.1% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: ABCB1

Entrez	5243 (Human)

Background:

P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas.

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Jump to: Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies

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Name	Catalog#	Reactivity	Applications	Images	Publications	Reviews
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MDR1 Antibody (JSB-1)	NBP1-51768	Ha, Mu(-), Rt(-)	FACS, IHC-Fr, IHC-P, WB
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RNAi (1)

Name	Catalog#	Reactivity	Applications	Images	Publications	Reviews
MDR1 RNAi	H00005243-R02	Hu		(1)	(4)

Secondary Antibodies

Name	Catalog#	Reactivity	Applications	Images	Publications
Rabbit IgG Antibody [HRP]	NB730-H	Rb	ELISA, ICC, IHC-P, WB		(5)
Rabbit IgG Antibody [FITC]	NB730-F	Rb	ICC, IHC-P		(1)
Rabbit IgG Antibody [Biotin]	NB730-B	Rb	ELISA, ICC, IHC-P, WB
Rabbit IgG, H/L Chains Antibody [DyLight 488]	NBP1-72944	Rb	FLISA, IF, WB	(3)
Rabbit IgG Antibody [Alkaline Phosphatase]	NB730-AP	Rb	ELISA, ICC, IHC-P, WB		(1)
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