Western Blot: LIN-61 Antibody [29590002] - This image is specific to animal number Q0824 1:500 Nuclear extract validation
Genetic Strategies: Immunocytochemistry/ Immunofluorescence: LIN-61 Antibody [29590002] - This image is specific to animal number Q0824 Nuclear signal decreased after RNAi lin-61 but didn't go away completely. ...read more
Western Blot: LIN-61 Antibody [29590002] - Detection of C. elegans LIN61 at a dilution of 1:3,000. LIN61 appeared at 57 kDa. Image courtesy of University of Cambridge, Ahringer Lab.
Immunocytochemistry/ Immunofluorescence: LIN-61 Antibody [29590002] - Staining of LIN 61 antibody at a dilution of 1:1,000. Image courtesy of University of Cambridge, Ahringer Lab.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
Preservative
No Preservative
Purity
Immunogen affinity purified
Notes
This product was created from the ModEncode Project, a part of the NHGRI, and is sold by SDIX and Novus Biologicals. These C. elegans antibodies were generated in the labs of Jason Lieb, Susan Strome, Julie Ahringer, Arshad Desai, and Abby Dernburg.
Background
lin-61 encodes a protein that contains four malignant brain tumor (MBT) repeats and is similar to the human and mouse lethal (3) malignant brain tumor 2 [L(3)MBT2] proteins; LIN-61 is predicted to function in a transcriptional regulatory complex that may play a role in transcriptional repression during development; loss of lin-61 activity via RNAi and mutation indicates that LIN-61 is required for: 1) genome stability in the soma and germline, and 2) postembryonic developmental processes such as vulval development, in which lin-61 acts as a class B synthetic multivulval (SynMuv) gene and as a candidate transcriptional repressor of genes such at mat-3; LIN-61 is broadly expressed throughout development, from the one-cell embryo through adulthood, and localizes to nuclei.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Publications for LIN-61 Antibody (29590002)(2)
We have publications tested in 1 application: MiAr.
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![Western Blot: LIN-61 Antibody [29590002] - This image is specific to animal number Q0824 1:500 Nuclear extract validation](http://images.novusbio.com/fullsize/LIN-61-Antibody-Western-Blot-29590002-img0008.jpg "Western Blot: LIN-61 Antibody [29590002] - This image is specific to animal number Q0824 1:500 Nuclear extract validation")
![Immunocytochemistry/Immunofluorescence: LIN-61 Antibody [29590002] - This image is specific to animal number Q0824 Nuclear signal decreased after RNAi lin-61 but didn't go away completely. Antibody dilution 1:1000](http://images.novusbio.com/fullsize/LIN-61-Antibody-Immunocytochemistry-Immunofluorescence-29590002-img0006.jpg "Immunocytochemistry/Immunofluorescence: LIN-61 Antibody [29590002] - This image is specific to animal number Q0824 Nuclear signal decreased after RNAi lin-61 but didn't go away completely. Antibody dilution 1:1000")
![Western Blot: LIN-61 Antibody [29590002] - Detection of C. elegans LIN61 at a dilution of 1:3,000. LIN61 appeared at 57 kDa. Image courtesy of University of Cambridge, Ahringer Lab.](http://images.novusbio.com/fullsize/LIN-61-Antibody-Western-Blot-29590002-img0007.jpg "Western Blot: LIN-61 Antibody [29590002] - Detection of C. elegans LIN61 at a dilution of 1:3,000. LIN61 appeared at 57 kDa. Image courtesy of University of Cambridge, Ahringer Lab.")
![Immunocytochemistry/Immunofluorescence: LIN-61 Antibody [29590002] - Staining of LIN 61 antibody at a dilution of 1:1,000. Image courtesy of University of Cambridge, Ahringer Lab.](http://images.novusbio.com/fullsize/LIN-61-Antibody-Immunocytochemistry-Immunofluorescence-29590002-img0005.jpg "Immunocytochemistry/Immunofluorescence: LIN-61 Antibody [29590002] - Staining of LIN 61 antibody at a dilution of 1:1,000. Image courtesy of University of Cambridge, Ahringer Lab.")