Insulin R/CD220 Antibody

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This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. ATP + a protein tyrosine = ADP + a protein tyrosine phosphate. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NB300-337	Applications	Species
Cappuzzo, F, Toschi, L, Tallini, G, Ceresoli, G L, Domenichini, I, Bartolini, S, Finocchiaro, G, Magrini, E, Metro, G, Cancellieri, A, Trisolini, R, Crino, L, Bunn, P A, Jr, Santoro, A, Franklin, W A, Varella-Garcia, M, Hirsch, F R. Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib. Ann Oncol17(7):1120-7. 2006-07-01 [PMID: 16600976]

Array NB300-337

• Insulin R/CD220 Antibodies
• Insulin R/CD220 ELISA Kits
• Insulin R/CD220 Protein
• Insulin R/CD220 ELISAs
• Insulin R/CD220 Proteins and Enzymes