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Recombinant Human beta-2 Adrenergic R/ADRB2 Protein

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Order Details


    • Catalog Number
      H00000154-G01
    • Availability
      Product Discontinued

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Recombinant Human beta-2 Adrenergic R/ADRB2 Protein Summary

Description
An untagged recombinant protein corresponding to the amino acid sequence of (NP_000015.1) for Human beta-2 Adrenergic R/ADRB2

Source: Wheat Germ

Amino Acid Sequence: MGQPGNGSAFLLAPNRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL

Details of Functionality
This protein is not active and should not be used for experiments requiring activity.
Source
Wheat germ
Protein/Peptide Type
Recombinant Protein
Gene
ADRB2
Purity
>20% by SDS-PAGE and Coomassie blue staining

Applications/Dilutions

Dilutions
  • Functional
  • Immunoaffinity Purification
Application Notes
Product may contain endotoxins and is not suitable for use with live cells.
Theoretical MW
46.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Preservative
No Preservative
Purity
>20% by SDS-PAGE and Coomassie blue staining

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Recombinant Human beta-2 Adrenergic R/ADRB2 Protein

  • ADRB2
  • ADRB2R
  • ADRBR
  • adrenergic, beta-2-, receptor, surface
  • B2AR
  • B2ARADRB2R
  • BAR
  • beta-2 Adrenergic R
  • beta-2 adrenergic receptor
  • beta2 AdrenergicR
  • beta-2 AdrenergicR
  • Beta-2 adrenoceptor
  • Beta-2 adrenoreceptor
  • BETA2AR
  • catecholamine receptor

Background

The beta-2 adrenoceptor (ADRB2) is an Adrenergic Receptor expressed in smooth muscle and metabolic tissues. Activation of this receptor induces a decrease in gastrointestinal motility, bronchodilation, vasodilation in skeletal and cardiac muscle, and glycogenolysis in liver. The beta-2 adrenoceptor is also a major lipolytic receptor in human fat cells and may be involved in obesity. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src, the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1). Expression of the beta-2 adrenoceptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel. ESTs have been isolated from breast, liver, liver/spleen, placenta, and uterus libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 1 year from date of receipt.

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Publications for beta-2 Adrenergic R/ADRB2 Recombinant Protein (H00000154-G01) (0)

There are no publications for beta-2 Adrenergic R/ADRB2 Recombinant Protein (H00000154-G01).
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FAQs for beta-2 Adrenergic R/ADRB2 Recombinant Protein (H00000154-G01). (Showing 1 - 1 of 1 FAQ).

  1. Since this is a membrane protein, does this product contain any detergent in the buffer? If yes, could you please provide some detailed info about the detergent, e.g. what detergent is in there.
    • Regarding your enquiry about ADRB2 (Human) Recombinant Protein (Catalog #: H00000154-G01), its storage buffer is only 25 mM Tris-HCl of pH8.0 containing 2% glycerol. Moreover, just a friendly sharing that the ADRB2 human recombinant protein is embedded in the liposomal membrane. In our experience, heating may cause membrane protein aggregation, and most of the membrane protein would be stuck on stacking gel when running SDS-PAGE. As membrane protein is easy aggregated after heating, we do not heat membrane protein. We mix the protein with sample buffer and load it to gel directly.

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Bioinformatics

Gene Symbol ADRB2