BAI1 Antibody

Brain-specific angiogenesis inhibitors, including BAI1, BAI-2 and BAI-3, are integral membrane proteins belonging to the G protein-coupled receptor 2 family. In addition to inhibiting angiogenesis in the brain, BAI proteins are also expressed in the heart, thymus, skeletal muscle, and a variety of cell lines. BAI1 protein is specifically expressed in the brain and found to localize to the cytoplasm and membrane in neuronal cells of the cerebral cortex. Reduced expression of BAI1 in some glioblastoma cell lines and cancer tissues implicates the functional role of BAI-1 as an inhibitor of angiogenesis. The exact mechanisms underlying BAI1 anti-angiogenetic activity are still being investigated. BAI1 may be involved in mediating the p53 signal in suppression of glioblastoma, as well as in cell adhesion and signal transduction. Additional research shows an inverse correlation with vascularization and BAI1 expression in both colorectal carcinomas and pulmonary adenocarcinomas.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Images	Ratings	Applications	Species	Date	Details
Enlarge	3 reviewed by: Joseph Huang	Flow	Human	08/10/2011	View Summary Application Flow Cytometry Sample Tested Human acute monocytic leukemia cell line Species Human
Enlarge	5 reviewed by: DAE-HEE LEE	ICC	Human	07/06/2011	View Summary Application Immunocytochemistry Sample Tested Human normal astrocyte cells Species Human
	5 reviewed by: Min Li	IF	Human	05/17/2011	View Summary Application Immunofluorescence Sample Tested THP1 cell line Species Human

Array NBP1-00723

• BAI1 Antibodies
• BAI1 ELISA Kits
• BAI1 Lysate
• BAI1 Protein
• BAI1 Proteins and Enzyme